Jay Cutler passed for 262 yards and two touchdowns, and the Chicago defense intercepted New York's Eli Manning three times, as the Bears beat the Giants, 27-21, at Soldier Field on Thursday night.
Brandon Weeden passed for 197 yards and a touchdown in relief of starter Brian Hoyer, and the Browns overcame an early deficit to beat the Buffalo Bills, 37-24, on Thursday night in Cleveland.
Frank Gore ran for 153 yards and a score, and Colin Kaepernick threw two touchdown passes as the San Francisco 49ers dominated the Rams, 35-11 in St. Louis on Thursday night.
Cincinnati forced five turnovers, including four in the second half, and the Bengals beat the Philadelphia Eagles, 34-13, in Philadelphia on Thursday night.
Rookie quarterback Andrew Luck ran for two touchdowns, and the Indianapolis Colts dominated the Jacksonville Jaguars, 27-10, in Jacksonville on Thursday night.
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Philip Rivers threw two touchdown passes and the Chargers’ defense added two late scores on Chiefs’ turnovers, as San Diego routed visiting Kansas City, 31-13, on Thursday night.